1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
CAS: 376382-11-5
Molecular Formula: C24H18N2O2
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione - Names and Identifiers
| Name | 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| Synonyms | 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| CAS | 376382-11-5 |
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione - Physico-chemical Properties
| Molecular Formula | C24H18N2O2 |
| Molar Mass | 366 |
| Solubility | DMSO: 10mg/mL |
| Storage Condition | -20℃ |
| Use | BRD7389 is RSK family kinase inhibitor. BRD7389 caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture. |
| Target | RSK1 RSK2 RSK3 CDK5/p35 DRAK1 FLT3 PIM1 PKG1α SGK |
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione - Reference
| Reference Show more | 1: Theodosakis N, Micevic G, Langdon CG, Ventura A, Means R, Stern DF, Bosenberg MW. p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis. J Invest Dermatol. 2017 Oct;137(10):2187-2196. doi: 10.1016/j.jid.2016.12.033. Epub 2017 Jun 7. PubMed PMID: 28599981. 2: Zhao H, Martin TA, Davies EL, Ruge F, Yu H, Zhang Y, Teng XU, Jiang WG. The Clinical Implications of RSK1-3 in Human Breast Cancer. Anticancer Res. 2016 Mar;36(3):1267-74. PubMed PMID: 26977024. 3: Choudhary A, Hu He K, Mertins P, Udeshi ND, Dančík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. PLoS One. 2014 Apr 23;9(4):e95194. doi: 10.1371/journal.pone.0095194. eCollection 2014. PubMed PMID: 24759943; PubMed Central PMCID: PMC3997365. 4: Park YS, Cho NJ. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov;370(1-2):191-8. doi: 10.1007/s11010-012-1410-z. Epub 2012 Aug 3. PubMed PMID: 22865467. 5: Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104. doi: 10.1073/pnas.10100181 |
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.732 ml | 13.661 ml | 27.322 ml |
| 5 mM | 0.546 ml | 2.732 ml | 5.464 ml |
| 10 mM | 0.273 ml | 1.366 ml | 2.732 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione Visit Supplier Webpage Request for quotation
CAS: 376382-11-5
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